(4-Aminopyridin-2-yl)methanol
Names and Identifiers of (4-Aminopyridin-2-yl)methanol
CAS Number |
100114-58-7 |
|---|---|
EC Number |
890-204-3 |
MDL Number |
MFCD11100581 |
IUPAC Name |
(4-aminopyridin-2-yl)methanol |
InChI |
InChI=1S/C6H8N2O/c7-5-1-2-8-6(3-5)4-9/h1-3,9H,4H2,(H2,7,8) |
InChIKey |
ZBKZWFGHOALGNP-UHFFFAOYSA-N |
Canonical SMILES |
C1=CN=C(C=C1N)CO |
UNSPSC Code |
12352100 |
Physical and chemical properties of (4-Aminopyridin-2-yl)methanol
Acidity coefficient |
13.40±0.10(Predicted) |
|---|---|
Boiling Point |
348.2ºC at 760 mmHg |
Density |
1.257g/cm3 |
Exact Mass |
124.06400 |
Flash Point |
164.4ºC |
Index of Refraction |
1.627 |
LogP |
0.73730 |
Melting Point |
114-115℃ |
Molecular Formula |
C6H8N2O |
Molecular Weight |
124.14100 |
PSA |
59.14000 |
Storage condition |
under inert gas (nitrogen or Argon) at 2–8 °C |
Vapour Pressure |
1.93E-05mmHg at 25°C |
Safety Information of (4-Aminopyridin-2-yl)methanol
Applications of (4-Aminopyridin-2-yl)methanol
(4-Aminopyridin-2-yl)methanol has several applications, particularly in pharmaceuticals:
- Neurological Research: Due to its potassium channel-blocking properties, it is being investigated for use in treating neurological conditions such as multiple sclerosis.
- Pain Management: Its role in modulating pain pathways suggests potential applications in analgesic formulations.
- Chemical Synthesis: As an intermediate in organic synthesis, it serves as a building block for more complex molecules.
The compound's unique properties make it valuable in both research and therapeutic contexts.
Interaction Studies of (4-Aminopyridin-2-yl)methanol
Studies on (4-Aminopyridin-2-yl)methanol have focused on its interactions with various biological targets:
- Potassium Channels: It has been shown to interact with voltage-gated potassium channels, leading to increased neuronal excitability.
- Receptors: Research indicates potential interactions with neurotransmitter receptors, which may enhance synaptic transmission.
These interactions are crucial for understanding the compound's mechanism of action and its potential therapeutic effects.
Biological Activity of (4-Aminopyridin-2-yl)methanol
Research has indicated that (4-Aminopyridin-2-yl)methanol exhibits various biological activities. It has been studied for its potential as a therapeutic agent in the treatment of neurological disorders, particularly multiple sclerosis and spinal cord injuries. The compound is believed to enhance neurotransmission by blocking potassium channels, thereby increasing neuronal excitability and conduction velocity.
Additionally, it has shown promise in modulating pain pathways and may have applications in pain management therapies.
Physical sample testing spectrum (NMR) of (4-Aminopyridin-2-yl)methanol
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