3-Iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine

3-Iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine and its derivatives have several applications:

• Pharmaceutical Development: Due to their activity against FGFRs, these compounds are being explored as potential anticancer agents.
• Chemical Probes: They serve as valuable tools in biological research for studying cellular signaling pathways related to cancer.
• Material Science: The unique properties of pyrrolo[2,3-b]pyridines make them suitable candidates for developing new materials with specific electronic or optical properties.

Interaction studies have focused on how 3-Iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine derivatives interact with biomolecules such as DNA and proteins. Molecular docking simulations suggest that these compounds can intercalate into DNA strands, potentially disrupting replication processes in cancer cells . Furthermore, studies indicate that they may inhibit specific kinases involved in cell signaling pathways critical for tumor growth.

Research indicates that derivatives of 3-Iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine exhibit promising biological activities, particularly as inhibitors of fibroblast growth factor receptors (FGFRs). These receptors play a crucial role in tumor progression and angiogenesis. Notably, some derivatives have shown potent inhibitory effects against FGFR1, FGFR2, and FGFR3, with IC₅₀ values in the nanomolar range. Additionally, these compounds have demonstrated antiproliferative effects on various cancer cell lines by inducing apoptosis and inhibiting cell migration and invasion .