structure of 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

CAS No.: 1000340-86-2
M. Wt: 157.172
M. Fa: C9H7N3
InChI Key: PMZKIGBJJTZXKW-UHFFFAOYSA-N
Appearance: White To Yellow Solid

Names and Identifiers of 1000340-86-2

CAS Number

1000340-86-2

MDL Number

MFCD09880162

IUPAC Name

6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

InChI

InChI=1S/C9H7N3/c1-6-8(5-10)4-7-2-3-11-9(7)12-6/h2-4H,1H3,(H,11,12)

InChIKey

PMZKIGBJJTZXKW-UHFFFAOYSA-N

Canonical SMILES

CC1=C(C=C2C=CNC2=N1)C#N

UNSPSC Code

12352100

Physical and chemical properties of 1000340-86-2

Density

1.3±0.1 g/cm3

Exact Mass

157.063995

H Bond Acceptors

2

H Bond Donors

1

Index of Refraction

1.658

LogP

2.55

Molecular Formula

C9H7N3

Molecular Weight

157.172

PSA

52.47000

Storage condition

2-8°C

Safety Information of 1000340-86-2

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 1000340-86-2

6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile has several applications:

  • Medicinal Chemistry: It is being explored as a therapeutic agent in cancer treatment due to its inhibitory effects on FGFRs.
  • Chemical Research: The compound serves as a building block for synthesizing more complex molecules in organic chemistry.
  • Biological Probes: It may be utilized in studies aimed at understanding biological systems and disease mechanisms.

Interaction Studies of 1000340-86-2

Research indicates that 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile interacts with specific molecular targets such as fibroblast growth factor receptors. By inhibiting these receptors, the compound can modulate signaling pathways critical for cell survival and proliferation. This mechanism underpins its potential therapeutic applications in oncology.

Biological Activity of 1000340-86-2

This compound has been investigated for its biological activities, particularly as an inhibitor of fibroblast growth factor receptors (FGFRs), which are implicated in various cancers. By inhibiting FGFR signaling pathways, 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile may interfere with tumor growth and proliferation, making it a promising candidate for cancer therapy.

Retrosynthesis analysis of 1000340-86-2

  • Route#1

    Cas:958358-00-4
    Cas:1000340-86-2