structure of 3-iodo-7-methyl-1H-pyrrolo[3,2-c]pyridine

3-iodo-7-methyl-1H-pyrrolo[3,2-c]pyridine

CAS No.: 1000341-37-6
M. Wt: 258.059
M. Fa: C8H7IN2
InChI Key: GIZAYPWXDPHLDX-UHFFFAOYSA-N

Names and Identifiers of 1000341-37-6

CAS Number

1000341-37-6

IUPAC Name

3-iodo-7-methyl-1H-pyrrolo[3,2-c]pyridine

InChI

InChI=1S/C8H7IN2/c1-5-2-10-3-6-7(9)4-11-8(5)6/h2-4,11H,1H3

InChIKey

GIZAYPWXDPHLDX-UHFFFAOYSA-N

Canonical SMILES

CC1=CN=CC2=C1NC=C2I

Physical and chemical properties of 1000341-37-6

Boiling Point

383.2±37.0 °C at 760 mmHg

Density

1.9±0.1 g/cm3

Exact Mass

257.965393

Flash Point

185.6±26.5 °C

Index of Refraction

1.750

LogP

2.14

Molecular Formula

C8H7IN2

Molecular Weight

258.059

PSA

28.68000

Vapour Pressure

0.0±0.8 mmHg at 25°C

Safety Information of 1000341-37-6

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 1000341-37-6

The applications of 3-iodo-7-methyl-1H-pyrrolo[3,2-c]pyridine are diverse:

  • Medicinal Chemistry: It is utilized as a building block for synthesizing biologically active molecules, particularly kinase inhibitors.
  • Chemical Biology: The compound is employed in studying biological pathways due to its ability to interact with various biological targets.
  • Material Science: It may also find applications in developing new materials owing to its unique chemical properties.

Interaction Studies of 1000341-37-6

Studies on the interactions of 3-iodo-7-methyl-1H-pyrrolo[3,2-c]pyridine with biological targets have revealed its potential as an inhibitor of specific enzymes. For instance, it has been investigated for its effects on H+/K+ ATPase, crucial in gastric acid secretion. These studies help elucidate its mechanism of action and guide further development for therapeutic applications.

Biological Activity of 1000341-37-6

3-Iodo-7-methyl-1H-pyrrolo[3,2-c]pyridine exhibits promising biological activities, particularly in medicinal chemistry. It serves as a scaffold for designing inhibitors targeting specific enzymes, especially those involved in kinase pathways relevant to cancer and other diseases. Its structure allows effective interaction with biological molecules, potentially modulating cellular processes such as proliferation and apoptosis. Notably, derivatives of this compound have shown activity against fibroblast growth factor receptors (FGFRs), which are implicated in various types of tumors.