structure of 3-Bromo-1H-pyrrolo[3,2-c]pyridine-4-carboxylic acid

3-Bromo-1H-pyrrolo[3,2-c]pyridine-4-carboxylic acid

CAS No.: 1000341-43-4
M. Wt: 241.042
M. Fa: C8H5BrN2O2
InChI Key: BSDGCRRFFXKHMG-UHFFFAOYSA-N

Names and Identifiers of 1000341-43-4

CAS Number

1000341-43-4

EC Number

971-984-5

IUPAC Name

3-bromo-1H-pyrrolo[3,2-c]pyridine-4-carboxylic acid

InChI

InChI=1S/C8H5BrN2O2/c9-4-3-11-5-1-2-10-7(6(4)5)8(12)13/h1-3,11H,(H,12,13)

InChIKey

BSDGCRRFFXKHMG-UHFFFAOYSA-N

Canonical SMILES

C1=CN=C(C2=C1NC=C2Br)C(=O)O

Physical and chemical properties of 1000341-43-4

Boiling Point

518.6±45.0 °C at 760 mmHg

Density

1.9±0.1 g/cm3

Exact Mass

239.953430

Flash Point

267.4±28.7 °C

Index of Refraction

1.766

LogP

0.60

Molecular Formula

C8H5BrN2O2

Molecular Weight

241.042

PSA

65.98000

Vapour Pressure

0.0±1.4 mmHg at 25°C

Safety Information of 1000341-43-4

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 1000341-43-4

3-Bromo-1H-pyrrolo[3,2-c]pyridine-4-carboxylic acid has several applications in scientific research:

  • Medicinal Chemistry: It is utilized as an intermediate for developing potential therapeutic agents.
  • Organic Synthesis: The compound serves as a versatile building block for synthesizing more complex heterocyclic compounds.
  • Biological Studies: It aids in understanding biological pathways and mechanisms related to signal transduction and cellular communication.

Interaction Studies of 1000341-43-4

Studies on the interactions of 3-bromo-1H-pyrrolo[3,2-c]pyridine-4-carboxylic acid with biological targets have highlighted its role in inhibiting specific enzymes and receptors. For example, its derivatives have been shown to effectively inhibit fibroblast growth factor receptors, which are implicated in various cancers. This inhibition mechanism underscores its potential as a therapeutic agent in oncology.

Biological Activity of 1000341-43-4

This compound has shown potential biological activity, particularly in medicinal chemistry. It serves as a building block for synthesizing therapeutic agents targeting various proteins involved in cancer and inflammatory diseases. Notably, derivatives of 3-bromo-1H-pyrrolo[3,2-c]pyridine-4-carboxylic acid have been identified as inhibitors of fibroblast growth factor receptors (FGFRs), which are crucial for cell proliferation and survival. Inhibition of these receptors can lead to reduced tumor growth and metastasis.