structure of 6-Methyl-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid

6-Methyl-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid

CAS No.: 1000342-19-7
M. Wt: 176.172
M. Fa: C9H8N2O2
InChI Key: VCWDSSJFLLOJPG-UHFFFAOYSA-N

Names and Identifiers of 1000342-19-7

CAS Number

1000342-19-7

MDL Number

MFCD09750008

IUPAC Name

6-methyl-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid

InChI

InChI=1S/C9H8N2O2/c1-5-2-8-6(3-10-5)7(4-11-8)9(12)13/h2-4,11H,1H3,(H,12,13)

InChIKey

VCWDSSJFLLOJPG-UHFFFAOYSA-N

Canonical SMILES

CC1=CC2=C(C=N1)C(=CN2)C(=O)O

UNSPSC Code

12352100

Physical and chemical properties of 1000342-19-7

Boiling Point

436.7±40.0 °C at 760 mmHg

Density

1.4±0.1 g/cm3

Exact Mass

176.058578

Flash Point

217.9±27.3 °C

H Bond Acceptors

3

H Bond Donors

2

Index of Refraction

1.709

LogP

0.96

Molecular Formula

C9H8N2O2

Molecular Weight

176.172

PSA

65.98000

Vapour Pressure

0.0±1.1 mmHg at 25°C

Safety Information of 1000342-19-7

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 1000342-19-7

The applications of 6-Methyl-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid span various fields:

  • Medicinal Chemistry: Investigated as a potential therapeutic agent targeting FGFRs in cancer treatment.
  • Organic Synthesis: Used as a building block for developing complex organic molecules.
  • Material Science: Explored for its properties in creating new materials and chemical processes.

Interaction Studies of 1000342-19-7

Studies on the interactions of 6-Methyl-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid have highlighted its specificity towards FGFRs. The compound has been shown to inhibit FGFR activity effectively, leading to reduced proliferation of cancer cells and triggering apoptotic pathways. Further research is ongoing to elucidate the full spectrum of its interactions with other biomolecules and its potential side effects in therapeutic contexts.

Biological Activity of 1000342-19-7

6-Methyl-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid has been investigated for its interaction with Fibroblast Growth Factor Receptors (FGFRs), particularly acting as an inhibitor at the colchicine-binding site. This inhibition is associated with potent anticancer activities, affecting cell proliferation and inducing apoptosis in cancer cell lines such as breast cancer. The compound's ability to modulate key signaling pathways makes it a candidate for further research in therapeutic applications.