structure of 4-Methoxy-1H-pyrrolo[3,2-c]pyridin-2(3H)-one

4-Methoxy-1H-pyrrolo[3,2-c]pyridin-2(3H)-one

CAS No.: 1000342-85-7
M. Wt: 164.16100
M. Fa: C8H8N2O2
InChI Key: IKSGJTZFSSJDNP-UHFFFAOYSA-N

Names and Identifiers of 1000342-85-7

CAS Number

1000342-85-7

MDL Number

MFCD08690140

IUPAC Name

4-methoxy-1,3-dihydropyrrolo[3,2-c]pyridin-2-one

InChI

InChI=1S/C8H8N2O2/c1-12-8-5-4-7(11)10-6(5)2-3-9-8/h2-3H,4H2,1H3,(H,10,11)

InChIKey

IKSGJTZFSSJDNP-UHFFFAOYSA-N

Canonical SMILES

COC1=NC=CC2=C1CC(=O)N2

UNSPSC Code

12352100

Physical and chemical properties of 1000342-85-7

Exact Mass

164.05900

H Bond Acceptors

3

H Bond Donors

1

LogP

0.66990

Molecular Formula

C8H8N2O2

Molecular Weight

164.16100

PSA

54.71000

Safety Information of 1000342-85-7

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 1000342-85-7

The unique structure of 4-Methoxy-1H-pyrrolo[3,2-c]pyridin-2(3H)-one lends itself to various applications:

  • Pharmaceutical Development: Its derivatives are being explored as potential drug candidates targeting specific diseases such as cancer and neurodegenerative disorders.
  • Chemical Probes: The compound can serve as a chemical probe for studying biological pathways involving specific receptors or enzymes.
  • Agricultural Chemicals: Due to its biological activity, it may find applications in developing agrochemicals aimed at pest control or plant growth regulation.

Interaction Studies of 1000342-85-7

Interaction studies involving 4-Methoxy-1H-pyrrolo[3,2-c]pyridin-2(3H)-one have focused on its binding affinity to various biological targets. For example:

  • Fibroblast Growth Factor Receptors: Studies have shown that derivatives can bind effectively to these receptors, inhibiting their activity and potentially reducing tumor growth.
  • Colchicine-Binding Sites: Some derivatives have been designed to interact with colchicine-binding sites on tubulin, affecting microtubule dynamics critical for cell division.

These interactions highlight the compound's potential as a lead structure for drug development.

Biological Activity of 1000342-85-7

Research indicates that 4-Methoxy-1H-pyrrolo[3,2-c]pyridin-2(3H)-one exhibits significant biological activities. It has been evaluated for its potential as an inhibitor of various enzymes and receptors involved in cancer progression and inflammation. For instance, derivatives of this compound have shown inhibitory effects on fibroblast growth factor receptors, which are implicated in tumor growth and metastasis. Additionally, it has been investigated for its analgesic and sedative properties in preclinical studies.