1-Benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridine

The applications of 1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridine are diverse:

• Pharmaceutical Development: As a scaffold for designing new anti-cancer drugs.
• Chemical Research: Used in studies focused on kinase inhibition and other biological pathways.
• Material Science: Potential applications in developing new materials due to its unique structural properties.

Interaction studies involving 1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridine typically focus on its binding affinity to various biological targets such as kinases and metal complexes. These studies reveal its potential as an effective ligand in coordination chemistry and its ability to modulate biological pathways through enzyme inhibition. The interactions often involve hydrogen bonding and π-stacking due to the aromatic nature of the compound.

Research indicates that compounds similar to 1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridine exhibit significant biological activities, particularly as potential anti-cancer agents. For instance, derivatives have shown efficacy as inhibitors of various kinases involved in cancer progression. Specific studies have demonstrated that related compounds can serve as N-donor ligands for cytotoxic platinum complexes, enhancing their therapeutic potential against cancer cell lines with IC50 values significantly lower than those of standard treatments like cisplatin.