(S)-4-(1-Aminoethyl)phenol hydrobromide
Names and Identifiers of 1001094-89-8
CAS Number |
1001094-89-8 |
|---|---|
MDL Number |
MFCD08436142 |
IUPAC Name |
4-[(1S)-1-aminoethyl]phenol;hydrobromide |
InChI |
InChI=1S/C8H11NO.BrH/c1-6(9)7-2-4-8(10)5-3-7;/h2-6,10H,9H2,1H3;1H/t6-;/m0./s1 |
InChIKey |
PZBBMKOZPQAHRA-RGMNGODLSA-N |
Canonical SMILES |
CC(C1=CC=C(C=C1)O)N.Br |
Isomeric SMILES |
C[C@@H](C1=CC=C(C=C1)O)N.Br |
UNSPSC Code |
12352100 |
Physical and chemical properties of 1001094-89-8
Exact Mass |
217.01000 |
|---|---|
LogP |
3.07030 |
Molecular Formula |
C8H12BrNO |
Molecular Weight |
218.09100 |
PSA |
46.25000 |
Safety Information of 1001094-89-8
Applications of 1001094-89-8
(S)-4-(1-Aminoethyl)phenol hydrobromide finds numerous applications across various fields:
- Pharmaceutical Development: It serves as a building block for synthesizing active pharmaceutical ingredients.
- Catalytic Asymmetric Synthesis: Its role in producing chiral amines makes it valuable in organic synthesis.
- Biochemical Research: The compound is utilized in studies exploring enzyme interactions and metabolic pathways .
Interaction Studies of 1001094-89-8
Studies on (S)-4-(1-Aminoethyl)phenol hydrobromide reveal its interactions with transaminase enzymes, which are crucial for its metabolic processes. The compound forms an external aldimine with pyridoxal-5′-phosphate, leading to various biochemical transformations. This interaction underscores its importance in the context of amino acid metabolism and pharmaceutical applications .
Biological Activity of 1001094-89-8
Research indicates that this compound exhibits significant biological activity, particularly in medicinal chemistry. Its derivatives have shown potential antileishmanial activity against Leishmania donovani, a protozoan parasite responsible for leishmaniasis. Studies have revealed that compounds similar to (S)-4-(1-Aminoethyl)phenol hydrobromide can effectively reduce parasite loads in infected models by targeting mitochondrial functions .
Physical sample testing spectrum (NMR) of 1001094-89-8
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