(3-Chloro-5-fluoro-4-hydroxyphenyl)boronic acid
CAS No.:
1003298-72-3
M. Wt:
190.36500
M. Fa:
C6H5BClFO3
InChI Key:
WETMDTXTPLMJHT-UHFFFAOYSA-N
Appearance:
White Solid
Names and Identifiers of 1003298-72-3
CAS Number |
1003298-72-3 |
|---|---|
MDL Number |
MFCD18447589 |
IUPAC Name |
(3-chloro-5-fluoro-4-hydroxyphenyl)boronic acid |
InChI |
InChI=1S/C6H5BClFO3/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,10-12H |
InChIKey |
WETMDTXTPLMJHT-UHFFFAOYSA-N |
Canonical SMILES |
B(C1=CC(=C(C(=C1)Cl)O)F)(O)O |
UNSPSC Code |
12352100 |
Physical and chemical properties of 1003298-72-3
Boiling Point |
335.5±52.0°C at 760 mmHg |
|---|---|
Exact Mass |
190.00000 |
Molecular Formula |
C6H5BClFO3 |
Molecular Weight |
190.36500 |
PSA |
60.69000 |
Storage condition |
under inert gas (nitrogen or Argon) at 2-8°C |
Safety Information of 1003298-72-3
Applications of 1003298-72-3
(3-Chloro-5-fluoro-4-hydroxyphenyl)boronic acid finds applications in several fields:
- Pharmaceuticals: As a building block for drug synthesis, particularly in developing anticancer agents and enzyme inhibitors.
- Bioconjugation: Used in labeling biomolecules due to its ability to form stable complexes with diols.
- Sensors: Its interaction with sugars and other diols makes it useful in developing biosensors for glucose detection.
Interaction Studies of 1003298-72-3
Studies on the interactions of (3-Chloro-5-fluoro-4-hydroxyphenyl)boronic acid focus on its binding affinity with biological targets:
- Protein Binding: Investigations into how this compound interacts with proteins can reveal its potential as an inhibitor or modulator of enzymatic activity.
- Cellular Uptake Studies: Understanding how this compound enters cells and its subsequent biological effects is crucial for evaluating its therapeutic potential.
Biological Activity of 1003298-72-3
(3-Chloro-5-fluoro-4-hydroxyphenyl)boronic acid has been investigated for its biological properties. Compounds containing boronic acids often exhibit:
- Anticancer Activity: Boronic acids have shown potential in inhibiting proteasome activity, which is crucial for cancer cell survival. This compound may target specific cancer-related pathways.
- Enzyme Inhibition: It can inhibit certain enzymes involved in metabolic pathways, making it a candidate for drug development against metabolic disorders.
Physical sample testing spectrum (NMR) of 1003298-72-3
Cas:150-46-9
