structure of 3',4'-dihydroxyetoposide

3',4'-dihydroxyetoposide

CAS No.: 100007-54-3
M. Wt: 574.530
M. Fa: C28H30O13
InChI Key: -

Names and Identifiers of 3',4'-dihydroxyetoposide

CAS Number

100007-54-3

Physical and chemical properties of 3',4'-dihydroxyetoposide

Boiling Point

824.3±65.0 °C at 760 mmHg

Density

1.6±0.1 g/cm3

Exact Mass

574.168640

Flash Point

275.5±27.8 °C

Index of Refraction

1.690

LogP

0.23

Melting Point

192-194°C

Molecular Formula

C28H30O13

Molecular Weight

574.530

Storage condition

-20°C Freezer

Vapour Pressure

0.0±3.1 mmHg at 25°C

Applications of 3',4'-dihydroxyetoposide

3',4'-Dihydroxyetoposide is primarily explored for its potential applications in cancer therapy due to its ability to inhibit DNA synthesis and promote apoptosis in tumor cells. Research continues into its effectiveness against various cancers and its potential advantages over traditional etoposide formulations.

Interaction Studies of 3',4'-dihydroxyetoposide

Studies have shown that 3',4'-dihydroxyetoposide interacts with various cellular components:

  • Topoisomerase II: Similar to etoposide, it forms a stable complex that inhibits the enzyme's function.
  • Reactive Oxygen Species: The compound may also generate free radicals, contributing to its cytotoxic effects.

These interactions are crucial for understanding both its therapeutic potential and possible side effects.

Biological Activity of 3',4'-dihydroxyetoposide

3',4'-Dihydroxyetoposide exhibits biological activities similar to those of etoposide, primarily through its mechanism of action on DNA topoisomerase II. This enzyme is crucial for DNA replication and repair, and inhibition leads to:

  • Induction of DNA strand breaks: The compound forms a complex with topoisomerase II and DNA, preventing the repair of double-stranded breaks.
  • Cell cycle arrest: It primarily affects the S and G2 phases of the cell cycle, leading to apoptosis in rapidly dividing cancer cells.