3-Amino-1-hydroxypyrrolidin-2-one
Names and Identifiers of 3-Amino-1-hydroxypyrrolidin-2-one
CAS Number |
1003-51-6 |
|---|---|
EC Number |
634-468-8 |
IUPAC Name |
3-amino-1-hydroxypyrrolidin-2-one |
InChI |
InChI=1S/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2 |
InChIKey |
HCKUBNLZMKAEIN-UHFFFAOYSA-N |
Canonical SMILES |
C1CN(C(=O)C1N)O |
UNII |
F2JLV9220T |
Physical and chemical properties of 3-Amino-1-hydroxypyrrolidin-2-one
Boiling Point |
258.6ºC at 760mmHg |
|---|---|
Density |
1.436g/cm3 |
Exact Mass |
116.05900 |
Flash Point |
110.2ºC |
H Bond Acceptors |
3 |
H Bond Donors |
2 |
Index of Refraction |
1.59 |
LogP |
-2.16078827998714 |
Melting Point |
184℃ |
Molecular Formula |
C4H8N2O2 |
Molecular Weight |
116.11900 |
PSA |
66.56000 |
Storage condition |
2-8°C |
Vapour Pressure |
0.002mmHg at 25°C |
Safety Information of 3-Amino-1-hydroxypyrrolidin-2-one
Applications of 3-Amino-1-hydroxypyrrolidin-2-one
3-Amino-1-hydroxypyrrolidin-2-one has several applications, particularly in medicinal chemistry:
- Neuroprotective Agent: Due to its neuroprotective properties, it is being explored as a potential therapeutic agent for neurodegenerative diseases.
- Pharmaceutical Development: The compound serves as a scaffold for developing new drugs targeting neurotransmitter systems.
- Research Tool: It is utilized in studies aimed at understanding neurotransmission and the pharmacological profiles of related compounds.
Interaction Studies of 3-Amino-1-hydroxypyrrolidin-2-one
Interaction studies involving 3-amino-1-hydroxypyrrolidin-2-one have focused on its binding affinity to various receptors in the central nervous system. It has been shown to interact with GABA receptors, enhancing inhibitory neurotransmission. Additionally, studies suggest that it may modulate glutamate receptors, which are critical in excitatory signaling pathways . These interactions underscore its potential as a therapeutic agent in treating neurological disorders.
Biological Activity of 3-Amino-1-hydroxypyrrolidin-2-one
Research indicates that 3-amino-1-hydroxypyrrolidin-2-one exhibits neuroprotective effects. It has been studied for its ability to modulate neurotransmission and protect neuronal cells from damage caused by excitotoxicity. The compound has shown promise in enhancing GABAergic activity, which is crucial for maintaining neuronal stability and preventing over-excitation . Additionally, it may have implications in treating conditions such as anxiety and epilepsy due to its influence on neurotransmitter systems.
Physical sample testing spectrum (NMR) of 3-Amino-1-hydroxypyrrolidin-2-one
Cas:1363373-26-5
