3-Amino-7-methyl-1H-indazole
CAS No.:
1000343-59-8
M. Wt:
147.177
M. Fa:
C8H9N3
InChI Key:
JYTHNNWTAZPKPW-UHFFFAOYSA-N
Appearance:
Solid
Names and Identifiers of 3-Amino-7-methyl-1H-indazole
CAS Number |
1000343-59-8 |
|---|---|
MDL Number |
MFCD09880079 |
IUPAC Name |
7-methyl-1H-indazol-3-amine |
InChI |
InChI=1S/C8H9N3/c1-5-3-2-4-6-7(5)10-11-8(6)9/h2-4H,1H3,(H3,9,10,11) |
InChIKey |
JYTHNNWTAZPKPW-UHFFFAOYSA-N |
Canonical SMILES |
CC1=C2C(=CC=C1)C(=NN2)N |
UNSPSC Code |
12352100 |
Physical and chemical properties of 3-Amino-7-methyl-1H-indazole
Boiling Point |
380.5±22.0 °C at 760 mmHg |
|---|---|
Density |
1.295±0.06 g/cm3 |
Exact Mass |
147.079651 |
Flash Point |
212.0±9.5 °C |
H Bond Acceptors |
2 |
H Bond Donors |
2 |
Index of Refraction |
1.737 |
LogP |
1.67 |
Melting Point |
187-189 ºC |
Molecular Formula |
C8H9N3 |
Molecular Weight |
147.177 |
PSA |
54.70000 |
Vapour Pressure |
0.0±0.9 mmHg at 25°C |
Water Solubility |
Very slightly soluble (0.72 g/L) (25 ºC) |
Safety Information of 3-Amino-7-methyl-1H-indazole
Applications of 3-Amino-7-methyl-1H-indazole
3-Amino-7-methyl-1H-indazole serves multiple roles in scientific research and industry:
- Pharmaceutical Development: Its derivatives are explored for their potential as anticancer and antimicrobial agents.
- Synthetic Chemistry: Acts as a building block in the synthesis of more complex heterocyclic compounds.
- Material Science: Investigated for its properties in developing new materials due to its unique structure.
Interaction Studies of 3-Amino-7-methyl-1H-indazole
Studies involving interaction assessments indicate that 3-amino-7-methyl-1H-indazole may interact with various biological targets:
- Enzyme Inhibition: Research has shown that indazole derivatives can inhibit key enzymes involved in cancer progression.
- Receptor Binding: Its structural characteristics allow it to bind to specific receptors, potentially modulating biological responses.
These interactions suggest its utility in drug design and development.
Biological Activity of 3-Amino-7-methyl-1H-indazole
Research indicates that 3-amino-7-methyl-1H-indazole exhibits significant biological activities, particularly in the realm of antimicrobial and anticancer properties. Its structural similarity to other bioactive indazole derivatives suggests potential interactions with biological targets such as enzymes and receptors.
- Antitumor Activity: Indazole derivatives have been shown to act as effective hinge-binding fragments in tyrosine kinase inhibitors, enhancing their anticancer efficacy.
- Antimicrobial Properties: Some studies have reported antibacterial activity associated with related indazole compounds, indicating that 3-amino-7-methyl-1H-indazole may also possess similar properties.
Physical sample testing spectrum (NMR) of 3-Amino-7-methyl-1H-indazole
Cas:1219024-56-2
