3-FORMYL-6-METHYL-5-NITRO-7-AZAINDOLE
Names and Identifiers of 3-FORMYL-6-METHYL-5-NITRO-7-AZAINDOLE
CAS Number |
1000340-24-8 |
|---|---|
IUPAC Name |
6-methyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde |
Canonical SMILES |
CC1=C(C=C2C(=CNC2=N1)C=O)[N+](=O)[O-] |
Physical and chemical properties of 3-FORMYL-6-METHYL-5-NITRO-7-AZAINDOLE
Density |
1.5±0.1 g/cm3 |
|---|---|
Exact Mass |
205.048737 |
Index of Refraction |
1.746 |
LogP |
2.22 |
Molecular Formula |
C9H7N3O3 |
Molecular Weight |
205.170 |
PSA |
91.57000 |
Applications of 3-FORMYL-6-METHYL-5-NITRO-7-AZAINDOLE
6-Methyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde has several applications across different fields:
- Chemistry: Serves as an intermediate in the synthesis of complex organic molecules.
- Biology: Investigated for its potential as a kinase inhibitor.
- Medicine: Explored for anticancer properties targeting specific signaling pathways.
- Industry: Utilized in developing novel materials and pharmaceuticals .
Interaction Studies of 3-FORMYL-6-METHYL-5-NITRO-7-AZAINDOLE
The interaction studies of 6-methyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde focus on its binding affinity and inhibitory effects on FGFRs. Molecular docking studies have shown that this compound can form hydrogen bonds with key residues in FGFRs, enhancing its potential as a therapeutic agent against tumors associated with aberrant FGFR signaling .
Biological Activity of 3-FORMYL-6-METHYL-5-NITRO-7-AZAINDOLE
Research indicates that 6-methyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde exhibits significant biological activity, particularly in the context of cancer research. It is being investigated as a potential inhibitor of fibroblast growth factor receptors (FGFRs), which play a crucial role in tumor growth and metastasis. The compound's unique structure allows it to interact effectively with FGFRs, potentially leading to new therapeutic strategies for cancer treatment .