4'-(Imidazol-1-yl)acetophenone
Names and Identifiers of 4'-(Imidazol-1-yl)acetophenone
CAS Number |
10041-06-2 |
|---|---|
EC Number |
233-123-5 |
MDL Number |
MFCD00005282 |
IUPAC Name |
1-(4-imidazol-1-ylphenyl)ethanone |
InChI |
InChI=1S/C11H10N2O/c1-9(14)10-2-4-11(5-3-10)13-7-6-12-8-13/h2-8H,1H3 |
InChIKey |
GAIQQJIMVVUTQN-UHFFFAOYSA-N |
Canonical SMILES |
CC(=O)C1=CC=C(C=C1)N2C=CN=C2 |
UNII |
KQU6ES7DSS |
UNSPSC Code |
12352100 |
Physical and chemical properties of 4'-(Imidazol-1-yl)acetophenone
Acidity coefficient |
4.99±0.10(Predicted) |
|---|---|
Boiling Point |
360.9ºC at 760 mmHg |
BRN |
608955 |
Density |
1.13g/cm3 |
Exact Mass |
186.07900 |
Flash Point |
172.1ºC |
Index of Refraction |
1.593 |
LogP |
2.07490 |
Melting Point |
108-110 °C(lit.) |
Molecular Formula |
C11H10N2O |
Molecular Weight |
186.21000 |
PSA |
34.89000 |
Solubility |
>27.9 [ug/mL] (The mean of the results at pH 7.4) |
Storage condition |
Sealed in dry,Room Temperature |
Vapour Pressure |
2.15E-05mmHg at 25°C |
Safety Information of 4'-(Imidazol-1-yl)acetophenone
Applications of 4'-(Imidazol-1-yl)acetophenone
The primary applications of 4'-(Imidazol-1-yl)acetophenone are in laboratory research and potentially in pharmaceutical development. Its use as a selective thromboxane synthesis inhibitor makes it valuable in studying blood clotting mechanisms and developing potential treatments for related disorders. Additionally, it is commonly used in biochemical research to investigate various cellular processes and signaling pathways.
Interaction Studies of 4'-(Imidazol-1-yl)acetophenone
While specific interaction studies are not detailed in the provided search results, the compound's ability to inhibit thromboxane synthesis suggests that it interacts with enzymes involved in the thromboxane biosynthetic pathway. Further research would be needed to elucidate its precise mechanisms of action and potential interactions with other biological molecules.
Similar Compounds: Comparison and Uniqueness4'-(Imidazol-1-yl)acetophenone belongs to a class of compounds that combine imidazole and acetophenone moieties. While specific comparisons are not provided in the search results, we can infer that its uniqueness likely stems from the particular arrangement of these functional groups, which contributes to its selective thromboxane synthesis inhibition.
Similar compounds might include:
- Other imidazole derivatives
- Various acetophenone derivatives
- Compounds with similar thromboxane synthesis inhibition properties
The specific positioning of the imidazole group at the 4' position of the acetophenone likely contributes to its unique biological activity and selectivity compared to related compounds.
Biological Activity of 4'-(Imidazol-1-yl)acetophenone
4'-(Imidazol-1-yl)acetophenone exhibits significant biological activity, particularly as a selective thromboxane synthesis inhibitor. Thromboxane is a lipid molecule involved in blood clotting and inflammation processes. By inhibiting its synthesis, this compound may have potential therapeutic applications in conditions related to blood clotting disorders or inflammatory diseases.
Physical sample testing spectrum (NMR) of 4'-(Imidazol-1-yl)acetophenone
