structure of 4-Aminopicolinamide

4-Aminopicolinamide

CAS No.: 100137-47-1
M. Wt: 137.13900
M. Fa: C6H7N3O
InChI Key: QKNCZYUYGMWQPB-UHFFFAOYSA-N
Appearance: Solid

Names and Identifiers of 4-Aminopicolinamide

CAS Number

100137-47-1

EC Number

843-042-2

MDL Number

MFCD08062892

IUPAC Name

4-aminopyridine-2-carboxamide

InChI

InChI=1S/C6H7N3O/c7-4-1-2-9-5(3-4)6(8)10/h1-3H,(H2,7,9)(H2,8,10)

InChIKey

QKNCZYUYGMWQPB-UHFFFAOYSA-N

Canonical SMILES

C1=CN=C(C=C1N)C(=O)N

UNSPSC Code

12352100

Physical and chemical properties of 4-Aminopicolinamide

Acidity coefficient

15.33±0.50(Predicted)

Boiling Point

413.0±30.0 °C(Predicted)

Density

1.323±0.06 g/cm3(Predicted)

Exact Mass

137.05900

LogP

1.04420

Melting Point

169 °C

Molecular Formula

C6H7N3O

Molecular Weight

137.13900

PSA

82.00000

Storage condition

Keep in dark place,Inert atmosphere,Room temperature

Safety Information of 4-Aminopicolinamide

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 4-Aminopicolinamide

4-Aminopicolinamide has several applications across different fields:

  • Pharmaceuticals: It is explored as a scaffold for developing new antifungal agents and other therapeutic compounds due to its biological activity.
  • Organic Synthesis: Its ability to participate in cross-coupling reactions makes it valuable for synthesizing complex organic molecules.
  • Catalysis: The compound's unique properties allow it to serve as a ligand in catalysis, enhancing reaction efficiency and selectivity.

Interaction Studies of 4-Aminopicolinamide

Interaction studies involving 4-Aminopicolinamide focus on its binding affinity to various biological targets. Notably, research has identified its interaction with Sec14p, elucidating the mechanism by which it inhibits fungal growth. This understanding aids in optimizing the compound's structure for enhanced efficacy against fungal infections. Furthermore, studies have explored its interactions with metal ions, which may enhance its catalytic properties.

Biological Activity of 4-Aminopicolinamide

4-Aminopicolinamide exhibits significant biological activity, particularly as an antifungal agent. Research indicates that compounds containing the picolinamide scaffold can inhibit key proteins involved in fungal metabolism, such as Sec14p in Saccharomyces cerevisiae. This inhibition is crucial for developing new antifungal therapies, especially against resistant strains. Additionally, its derivatives have shown promise in targeting other biological pathways, potentially leading to novel therapeutic applications.

Physical sample testing spectrum (NMR) of 4-Aminopicolinamide

Physical sample testing spectrum (NMR) of 4-Aminopicolinamide