structure of 4-CHLORO-7-FLUORO (1H)INDAZOLE

4-CHLORO-7-FLUORO (1H)INDAZOLE

CAS No.: 1000341-84-3
M. Wt: 170.572
M. Fa: C7H4ClFN2
InChI Key: -

Names and Identifiers of 4-CHLORO-7-FLUORO (1H)INDAZOLE

CAS Number

1000341-84-3

IUPAC Name

4-chloranyl-7-fluoranyl-1H-indazole

Canonical SMILES

C1=CC(=C2C=NNC2=C1F)Cl

Physical and chemical properties of 4-CHLORO-7-FLUORO (1H)INDAZOLE

Boiling Point

311.6±22.0 °C at 760 mmHg

Density

1.5±0.1 g/cm3

Exact Mass

170.004700

Flash Point

142.3±22.3 °C

Index of Refraction

1.669

LogP

2.42

Molecular Formula

C7H4ClFN2

Molecular Weight

170.572

PSA

28.68000

Vapour Pressure

0.0±0.6 mmHg at 25°C

Applications of 4-CHLORO-7-FLUORO (1H)INDAZOLE

4-chloro-7-fluoro-1H-indazole has potential applications in various fields:

  • Pharmaceuticals: Due to its biological activity, it may serve as a lead compound for developing new drugs targeting microbial infections or parasitic diseases.
  • Material Science: Its ability to form complexes with metals makes it useful in photonic materials and sensors.

Interaction Studies of 4-CHLORO-7-FLUORO (1H)INDAZOLE

Research into the molecular interactions of 4-chloro-7-fluoro-1H-indazole highlights its capacity to engage in various bonding interactions. Studies have indicated that it can participate in C–H⋯π and C–H⋯X interactions (where X represents halogens), which are significant for understanding its crystallization behavior and stability in pharmaceutical formulations.

Biological Activity of 4-CHLORO-7-FLUORO (1H)INDAZOLE

Indazole derivatives, including 4-chloro-7-fluoro-1H-indazole, have demonstrated a range of biological activities. They are known for their potential as antimicrobial agents and inhibitors of various enzymes:

  • Inhibition of Lactoperoxidase: Studies have shown that indazole derivatives can inhibit lactoperoxidase activity, which is important for antimicrobial defense in biological systems.
  • Antiparasitic Activity: Some indazole derivatives have shown efficacy against parasites such as Trypanosoma cruzi and Leishmania species, suggesting their potential use in treating parasitic infections.