structure of 4-Chloro-7-methoxy-1H-indazole

4-Chloro-7-methoxy-1H-indazole

CAS No.: 1000341-90-1
M. Wt: 182.607
M. Fa: C8H7ClN2O
InChI Key: VKHMRJUJCBJRFT-UHFFFAOYSA-N

Names and Identifiers of 4-Chloro-7-methoxy-1H-indazole

CAS Number

1000341-90-1

MDL Number

MFCD28393020

IUPAC Name

4-chloro-7-methoxy-1H-indazole

InChI

InChI=1S/C8H7ClN2O/c1-12-7-3-2-6(9)5-4-10-11-8(5)7/h2-4H,1H3,(H,10,11)

InChIKey

VKHMRJUJCBJRFT-UHFFFAOYSA-N

Canonical SMILES

COC1=C2C(=C(C=C1)Cl)C=NN2

UNSPSC Code

12352100

Physical and chemical properties of 4-Chloro-7-methoxy-1H-indazole

Acidity coefficient

12.15±0.40(Predicted)

Boiling Point

348.2±22.0 °C at 760 mmHg

Density

1.4±0.1 g/cm3

Exact Mass

182.024689

Flash Point

164.4±22.3 °C

H Bond Acceptors

2

H Bond Donors

1

Index of Refraction

1.657

LogP

2.42

Molecular Formula

C8H7ClN2O

Molecular Weight

182.607

PSA

37.91000

Storage condition

2-8°C

Vapour Pressure

0.0±0.7 mmHg at 25°C

Safety Information of 4-Chloro-7-methoxy-1H-indazole

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 4-Chloro-7-methoxy-1H-indazole

4-Chloro-7-methoxy-1H-indazole finds applications in multiple fields:

  • Pharmaceutical Development: Due to its potential biological activities, it serves as a lead compound for developing new drugs targeting cancer or microbial infections.
  • Research: It is utilized in studies exploring the structure-activity relationship of indazoles and their derivatives.
  • Chemical Probes: The compound can act as a chemical probe in biological assays to elucidate mechanisms of action in various pathways.

Interaction Studies of 4-Chloro-7-methoxy-1H-indazole

Interaction studies involving 4-chloro-7-methoxy-1H-indazole focus on its binding affinity with various biological targets, including enzymes and receptors. These studies help elucidate its mechanism of action and potential therapeutic effects.

For example, research has indicated that certain indazoles can inhibit specific enzymes involved in cancer progression or microbial resistance mechanisms.

Biological Activity of 4-Chloro-7-methoxy-1H-indazole

Indazole derivatives, including 4-chloro-7-methoxy-1H-indazole, exhibit a range of biological activities:

  • Antitumor Activity: Some studies indicate that indazole compounds may possess cytotoxic properties against various cancer cell lines.
  • Antimicrobial Properties: Indazoles have been reported to show activity against certain bacteria and fungi.
  • CNS Activity: Research suggests that some indazoles may have potential neuroprotective effects, influencing conditions such as anxiety and depression.