5-METHOXY-6-METHYL-7-AZAINDOLE
Names and Identifiers of 5-METHOXY-6-METHYL-7-AZAINDOLE
CAS Number |
1000340-90-8 |
|---|---|
IUPAC Name |
5-methoxy-6-methyl-1H-pyrrolo[2,3-b]pyridine |
Canonical SMILES |
CC1=C(C=C2C=CNC2=N1)OC |
Physical and chemical properties of 5-METHOXY-6-METHYL-7-AZAINDOLE
Density |
1.2±0.1 g/cm3 |
|---|---|
Exact Mass |
162.079315 |
Index of Refraction |
1.629 |
LogP |
2.63 |
Molecular Formula |
C9H10N2O |
Molecular Weight |
162.189 |
PSA |
37.91000 |
Applications of 5-METHOXY-6-METHYL-7-AZAINDOLE
5-Methoxy-6-methyl-1H-pyrrolo[2,3-b]pyridine has potential applications in various fields:
- Pharmaceutical Development: As an FGFR inhibitor, it is being explored for its therapeutic potential in treating cancers associated with aberrant FGFR signaling.
- Chemical Biology: The compound serves as a tool for studying FGFR-related pathways and mechanisms.
- Material Science: Its unique structure may find applications in the development of novel materials with specific electronic or optical properties.
Interaction Studies of 5-METHOXY-6-METHYL-7-AZAINDOLE
Studies have shown that 5-methoxy-6-methyl-1H-pyrrolo[2,3-b]pyridine interacts effectively with FGFRs through hydrogen bonding and hydrophobic interactions. Specifically, the methoxy group can occupy hydrophobic pockets within the receptor's active site, enhancing binding affinity and specificity. This interaction profile is crucial for its biological efficacy and therapeutic potential.
Biological Activity of 5-METHOXY-6-METHYL-7-AZAINDOLE
Research indicates that 5-methoxy-6-methyl-1H-pyrrolo[2,3-b]pyridine exhibits significant biological activity, particularly as an inhibitor of Fibroblast Growth Factor Receptors (FGFRs). These receptors play crucial roles in cell proliferation, differentiation, and survival. Inhibition of FGFRs by this compound can lead to decreased cell proliferation and increased apoptosis in cancer cells, making it a candidate for anticancer therapies.