6-Chloro-5-methyl-1H-indazole
CAS No.:
1000341-02-5
M. Wt:
166.608
M. Fa:
C8H7ClN2
InChI Key:
GOPYPRVEHGZBJY-UHFFFAOYSA-N
Appearance:
Solid
Names and Identifiers of 6-Chloro-5-methyl-1H-indazole
CAS Number |
1000341-02-5 |
|---|---|
MDL Number |
MFCD09880179 |
IUPAC Name |
6-chloro-5-methyl-1H-indazole |
InChI |
InChI=1S/C8H7ClN2/c1-5-2-6-4-10-11-8(6)3-7(5)9/h2-4H,1H3,(H,10,11) |
InChIKey |
GOPYPRVEHGZBJY-UHFFFAOYSA-N |
Canonical SMILES |
CC1=CC2=C(C=C1Cl)NN=C2 |
UNSPSC Code |
12352100 |
Physical and chemical properties of 6-Chloro-5-methyl-1H-indazole
Acidity coefficient |
13.05±0.40(Predicted) |
|---|---|
Boiling Point |
321.7±22.0 °C at 760 mmHg |
Density |
1.4±0.1 g/cm3 |
Exact Mass |
166.029770 |
Flash Point |
178.0±7.9 °C |
Index of Refraction |
1.675 |
LogP |
2.88 |
Molecular Formula |
C8H7ClN2 |
Molecular Weight |
166.608 |
PSA |
28.68000 |
Storage condition |
Sealed in dry,Room Temperature |
Vapour Pressure |
0.0±0.7 mmHg at 25°C |
Safety Information of 6-Chloro-5-methyl-1H-indazole
Applications of 6-Chloro-5-methyl-1H-indazole
6-Chloro-5-methyl-1H-indazole has potential applications in several fields:
- Pharmaceutical Development: Its biological activity makes it a candidate for drug development, particularly in targeting cancer pathways.
- Chemical Research: As a building block in organic synthesis, it can be utilized to create various indazole derivatives for further study.
Biological Activity of 6-Chloro-5-methyl-1H-indazole
Research indicates that 6-chloro-5-methyl-1H-indazole and its derivatives exhibit significant biological activities, including:
- Inhibition of Protein Kinase B/Akt: Some derivatives have shown potential as inhibitors of protein kinase B, a critical pathway in cancer cell survival and proliferation.
- Antiviral Properties: Certain studies suggest that related compounds may possess antiviral activity, although specific data on 6-chloro-5-methyl-1H-indazole is limited.
Physical sample testing spectrum (NMR) of 6-Chloro-5-methyl-1H-indazole
