structure of 6-Methoxy-4-nitro-1H-indazole

6-Methoxy-4-nitro-1H-indazole

CAS No.: 1000341-08-1
M. Wt: 193.160
M. Fa: C8H7N3O3
InChI Key: ACUQZJBBTADFHU-UHFFFAOYSA-N

Names and Identifiers of 6-Methoxy-4-nitro-1H-indazole

CAS Number

1000341-08-1

IUPAC Name

6-methoxy-4-nitro-1H-indazole

InChI

InChI=1S/C8H7N3O3/c1-14-5-2-7-6(4-9-10-7)8(3-5)11(12)13/h2-4H,1H3,(H,9,10)

InChIKey

ACUQZJBBTADFHU-UHFFFAOYSA-N

Canonical SMILES

COC1=CC2=C(C=NN2)C(=C1)[N+](=O)[O-]

Physical and chemical properties of 6-Methoxy-4-nitro-1H-indazole

Boiling Point

427.9±25.0 °C at 760 mmHg

Density

1.5±0.1 g/cm3

Exact Mass

193.048737

Flash Point

212.6±23.2 °C

Index of Refraction

1.686

LogP

1.77

Molecular Formula

C8H7N3O3

Molecular Weight

193.160

PSA

83.73000

Storage condition

2-8°C

Vapour Pressure

0.0±1.0 mmHg at 25°C

Safety Information of 6-Methoxy-4-nitro-1H-indazole

Pictograms

Signal Word

 Warning

Safety Data Sheet
Supports customized editing of SDS information and downloading in PDF documents.

Applications of 6-Methoxy-4-nitro-1H-indazole

The unique properties and biological activities of 6-methoxy-4-nitro-1H-indazole make it suitable for various applications:

  • Pharmaceutical Development: Its enzyme inhibition capabilities make it a candidate for developing treatments for diseases like Parkinson's and Alzheimer's.
  • Chemical Research: As a building block in organic synthesis, it can serve as an intermediate in creating more complex molecules.

Interaction Studies of 6-Methoxy-4-nitro-1H-indazole

Interaction studies indicate that 6-methoxy-4-nitro-1H-indazole interacts with various biological targets. Notably:

  • Enzyme Binding Affinity: Studies have demonstrated its binding affinity to monoamine oxidase B and nitric oxide synthase, which are critical for understanding its therapeutic potential.

These interactions are essential for elucidating the compound's mechanism of action and potential side effects.

Biological Activity of 6-Methoxy-4-nitro-1H-indazole

6-Methoxy-4-nitro-1H-indazole has been studied for its biological activities, particularly its inhibitory effects on important enzyme systems. Notably:

  • Monoamine Oxidase B Inhibition: The compound has shown potential as an inhibitor of monoamine oxidase B, an enzyme linked to neurodegenerative diseases.
  • Nitric Oxide Synthase Inhibition: It also inhibits neuronal nitric oxide synthase, indicating possible applications in neurological research and therapeutics.

These activities suggest that 6-methoxy-4-nitro-1H-indazole could play a role in drug development targeting neurological conditions.