8-Fluoroquinoline-5-sulfonyl chloride
Names and Identifiers of 8-Fluoroquinoline-5-sulfonyl chloride
CAS Number |
1000933-89-0 |
|---|---|
EC Number |
843-234-6 |
MDL Number |
MFCD09702325 |
IUPAC Name |
8-fluoroquinoline-5-sulfonyl chloride |
InChI |
InChI=1S/C9H5ClFNO2S/c10-15(13,14)8-4-3-7(11)9-6(8)2-1-5-12-9/h1-5H |
InChIKey |
WFHNJMBOSBJIPK-UHFFFAOYSA-N |
Canonical SMILES |
C1=CC2=C(C=CC(=C2N=C1)F)S(=O)(=O)Cl |
UNSPSC Code |
12352100 |
Physical and chemical properties of 8-Fluoroquinoline-5-sulfonyl chloride
Acidity coefficient |
-0.82±0.29(Predicted) |
|---|---|
Boiling Point |
365.6±27.0 °C(Predicted) |
Density |
1.558±0.06 g/cm3(Predicted) |
H Bond Acceptors |
3 |
H Bond Donors |
0 |
LogP |
2.219905436 |
Molecular Formula |
C9H5ClFNO2S |
Molecular Weight |
245.66 |
Storage condition |
2-8°C, sealed storage, away from moisture |
Safety Information of 8-Fluoroquinoline-5-sulfonyl chloride
Applications of 8-Fluoroquinoline-5-sulfonyl chloride
8-Fluoroquinoline-5-sulfonyl chloride has diverse applications across various fields:
- Pharmaceuticals: It serves as an intermediate in synthesizing drugs targeting bacterial infections and other diseases due to its bioactive derivatives.
- Agrochemicals: The compound is also explored for developing agrochemicals that can enhance crop protection against pests and diseases.
- Dyes and Pigments: Its derivatives find applications in producing dyes and pigments due to their structural properties.
Interaction Studies of 8-Fluoroquinoline-5-sulfonyl chloride
Interaction studies involving 8-fluoroquinoline-5-sulfonyl chloride focus on its reactivity with various biological targets. For example, it has been investigated for its potential interactions with enzymes that are critical in metabolic pathways. These studies help elucidate its mechanism of action and guide the design of more effective inhibitors based on its structure.
Biological Activity of 8-Fluoroquinoline-5-sulfonyl chloride
The biological activity of 8-fluoroquinoline-5-sulfonyl chloride is notable in its role as an intermediate in drug development. It has been utilized in synthesizing enzyme inhibitors and other biologically active compounds. The presence of the fluorine atom enhances its pharmacological properties, potentially increasing the lipophilicity and bioavailability of derived compounds. Moreover, its derivatives may exhibit antibacterial properties, making them candidates for treating various infections.
Physical sample testing spectrum (NMR) of 8-Fluoroquinoline-5-sulfonyl chloride
