structure of Eucatropine

Eucatropine

CAS No.: 100-91-4
M. Wt: 291.38500
M. Fa: C17H25NO3
InChI Key: QSAVEGSLJISCDF-UHFFFAOYSA-N

Names and Identifiers of Eucatropine

CAS Number

100-91-4

EC Number

202-900-0

IUPAC Name

(1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate

InChI

InChI=1S/C17H25NO3/c1-12-10-14(11-17(2,3)18(12)4)21-16(20)15(19)13-8-6-5-7-9-13/h5-9,12,14-15,19H,10-11H2,1-4H3

InChIKey

QSAVEGSLJISCDF-UHFFFAOYSA-N

Canonical SMILES

CC1CC(CC(N1C)(C)C)OC(=O)C(C2=CC=CC=C2)O

UNII

4SPJ105W8E

Physical and chemical properties of Eucatropine

Boiling Point

388.7ºC at 760mmHg

Density

1.11g/cm3

Exact Mass

291.18300

Flash Point

188.8ºC

LogP

2.46240

Molecular Formula

C17H25NO3

Molecular Weight

291.38500

PSA

49.77000

Vapour Pressure

9.97E-08mmHg at 25°C

Applications of Eucatropine

Eucatropine has several applications in medicine and research:

  • Anticholinergic Agent: It is used to manage conditions associated with excessive cholinergic activity, such as bronchospasm and gastrointestinal disorders.
  • Research Tool: Eucatropine serves as a valuable tool in pharmacological studies aimed at understanding muscarinic receptor functions and their implications in various diseases.

Interaction Studies of Eucatropine

Interaction studies involving Eucatropine have demonstrated its ability to bind selectively to muscarinic receptors. These studies often assess the compound's affinity (Ki values) across different receptor subtypes (M1, M2, M3) and analyze its pharmacokinetics and metabolism. For instance, Eucatropine has shown stability under physiological conditions, indicating potential for therapeutic use without rapid degradation.

Biological Activity of Eucatropine

Eucatropine exhibits significant biological activity as a muscarinic acetylcholine receptor antagonist. It has been shown to produce behavioral effects through central cholinoceptive sites in animal models, particularly in cats. Its antagonistic action on mAChRs contributes to its therapeutic effects, such as reducing secretions and muscle spasms associated with various conditions.