structure of K252d

K252d

CAS No.: 105114-22-5
M. Wt: 457.47800
M. Fa: C26H23N3O5
InChI Key: -

Names and Identifiers of K252d

CAS Number

105114-22-5

IUPAC Name

3-[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one

Canonical SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)N2C3=CC=CC=C3C4=C5C(=C6C7=CC=CC=C7NC6=C42)CNC5=O)O)O)O

Physical and chemical properties of K252d

Exact Mass

457.16400

LogP

3.00120

Molecular Formula

C26H23N3O5

Molecular Weight

457.47800

PSA

119.74000

Applications of K252d

K252d has several applications across different fields:

  • Pharmaceutical Research: Due to its protein kinase C inhibitory activity, it is studied for potential use in cancer therapies and neuroprotective treatments.
  • Agricultural Science: Research indicates that K252d may help suppress bacterial blight in rice, suggesting its utility as a biopesticide .
  • Biochemical Research: It serves as a valuable tool for studying protein kinase C signaling pathways and their implications in various diseases.

Interaction Studies of K252d

Studies on K252d interactions reveal its potential effects on various biological pathways:

  • Protein Kinase C Pathway: K252d specifically inhibits protein kinase C activity, which can alter downstream signaling cascades involved in cell growth and differentiation.
  • Synergistic Effects with Other Compounds: Research indicates that combining K252d with other anticancer agents may enhance therapeutic efficacy against resistant cancer cell lines.

Biological Activity of K252d

K252d exhibits significant biological activities, primarily attributed to its role as a protein kinase C inhibitor. Its biological effects include:

  • Anticancer Properties: K252d has shown cytotoxic effects against various cancer cell lines, making it a candidate for cancer therapy .
  • Neuroprotective Effects: By inhibiting protein kinase C, K252d may protect neuronal cells from apoptosis and oxidative stress.
  • Antimicrobial Activity: Some studies suggest that K252d possesses antimicrobial properties, potentially useful in treating bacterial infections .