structure of Rolicyprine

Rolicyprine

CAS No.: 2829-19-8
M. Wt: 244.28900
M. Fa: C14H16N2O2
InChI Key: UGSLDMJXBQKDCT-UHFFFAOYSA-N

Names and Identifiers of Rolicyprine

CAS Number

2829-19-8

IUPAC Name

5-oxo-N-(2-phenylcyclopropyl)pyrrolidine-2-carboxamide

InChI

InChI=1S/C14H16N2O2/c17-13-7-6-11(15-13)14(18)16-12-8-10(12)9-4-2-1-3-5-9/h1-5,10-12H,6-8H2,(H,15,17)(H,16,18)

InChIKey

UGSLDMJXBQKDCT-UHFFFAOYSA-N

Canonical SMILES

C1CC(=O)NC1C(=O)NC2CC2C3=CC=CC=C3

Physical and chemical properties of Rolicyprine

Exact Mass

244.12100

LogP

1.65700

Melting Point

144-147°

Molecular Formula

C14H16N2O2

Molecular Weight

244.28900

PSA

58.20000

Specific rotation

D25 +104.28° (DMF)

Vapour Pressure

5.26E-13mmHg at 25°C

Applications of Rolicyprine

Rolicyprine's primary applications lie within the pharmaceutical industry due to its sodium channel blocking properties. Potential uses include:

  • Antiepileptic Drugs: Its ability to stabilize neuronal activity makes it a candidate for developing medications for epilepsy.
  • Cardiac Treatments: As a sodium channel blocker, it may be beneficial in treating various cardiac arrhythmias.
  • Research: Rolicyprine serves as a valuable tool in studies related to ion channel physiology and pharmacology.

Interaction Studies of Rolicyprine

Studies on rolicyprine's interactions reveal important insights into its pharmacodynamics. Research indicates that rolicyprine interacts with various ion channels, influencing their activity and contributing to its therapeutic effects. The specificity of these interactions is crucial for minimizing side effects while maximizing efficacy in target applications.

Biological Activity of Rolicyprine

Rolicyprine exhibits notable biological activities, primarily as a sodium channel blocker. This property makes it a candidate for therapeutic applications in conditions such as epilepsy and cardiac arrhythmias. The mechanism of action involves the inhibition of sodium ion influx through voltage-gated sodium channels, which can stabilize neuronal membranes and reduce excitability.