Sulofenur
CAS No.:
110311-27-8
M. Wt:
350.82000
M. Fa:
C16H15ClN2O3S
InChI Key:
-
Names and Identifiers of Sulofenur
CAS Number |
110311-27-8 |
|---|---|
IUPAC Name |
1-(4-chlorophenyl)-3-(2,3-dihydro-1H-inden-5-ylsulfonyl)urea |
Canonical SMILES |
C1CC2=C(C1)C=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)Cl |
Physical and chemical properties of Sulofenur
Density |
1.449g/cm3 |
|---|---|
Exact Mass |
350.04900 |
Index of Refraction |
1.656 |
LogP |
4.88380 |
Melting Point |
169-172 °C |
Molecular Formula |
C16H15ClN2O3S |
Molecular Weight |
350.82000 |
PSA |
83.65000 |
Applications of Sulofenur
Sulofenur has potential applications primarily in oncology due to its antitumor properties. It is being investigated for use in treating various cancers, including:
- Solid tumors
- Hematological malignancies
Additionally, ongoing studies aim to explore its utility in combination therapies to enhance efficacy and reduce resistance.
Interaction Studies of Sulofenur
Studies on sulofenur interactions have revealed important insights into its mechanism of action and potential side effects:
- Calcium Dynamics: Research indicates that sulofenur affects intracellular calcium levels, which can lead to cytotoxic effects in cancer cells.
- Metabolic Pathways: The metabolism of sulofenur involves glutathione conjugation, highlighting its interaction with cellular detoxification mechanisms.
These interactions are critical for understanding both the therapeutic potential and the safety profile of sulofenur.