Tr-PEG5
CAS No.:
125274-16-0
M. Wt:
436.54000
M. Fa:
C27H32O5
InChI Key:
NVNUQXMSFVIKJG-UHFFFAOYSA-N
Appearance:
Yellow Sticky Liquid
Names and Identifiers of Tr-PEG5
CAS Number |
125274-16-0 |
|---|---|
IUPAC Name |
2-[2-[2-(2-trityloxyethoxy)ethoxy]ethoxy]ethanol |
InChI |
InChI=1S/C27H32O5/c28-16-17-29-18-19-30-20-21-31-22-23-32-27(24-10-4-1-5-11-24,25-12-6-2-7-13-25)26-14-8-3-9-15-26/h1-15,28H,16-23H2 |
InChIKey |
NVNUQXMSFVIKJG-UHFFFAOYSA-N |
Canonical SMILES |
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCCOCCOCCOCCO |
Physical and chemical properties of Tr-PEG5
Exact Mass |
436.22500 |
|---|---|
LogP |
4.03720 |
Molecular Formula |
C27H32O5 |
Molecular Weight |
436.54000 |
PSA |
57.15000 |
Safety Information of Tr-PEG5
Applications of Tr-PEG5
The primary applications of Tr-PEG5 include:
- Antibody-Drug Conjugates: Used as a linker to attach therapeutic agents to antibodies for targeted drug delivery.
- Bioconjugation: Serves as a spacer in various bioconjugation strategies, improving the stability and solubility of conjugated products.
- Drug Formulation: Enhances the solubility and bioavailability of poorly soluble drugs.
Interaction Studies of Tr-PEG5
Interaction studies involving Tr-PEG5 focus on its ability to enhance binding affinity and specificity in biological systems. For instance:
- Protein Interactions: Tr-PEG5-modified proteins often show improved interactions with target receptors due to increased solubility and reduced steric hindrance.
- Cellular Uptake: Studies have indicated that PEGylated compounds exhibit enhanced cellular uptake compared to non-modified versions, facilitating better therapeutic outcomes.
Biological Activity of Tr-PEG5
Tr-PEG5 exhibits significant biological activity primarily due to its role as a linker in antibody-drug conjugates (ADCs). The hydrophilic nature of PEG enhances the pharmacokinetics of drugs by improving solubility and stability in biological systems. Additionally, PEGylation can reduce immunogenicity and prolong circulation time in vivo. Studies have shown that compounds modified with Tr-PEG5 demonstrate improved therapeutic efficacy and reduced toxicity compared to their unmodified counterparts.
Physical sample testing spectrum (NMR) of Tr-PEG5
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