structure of Tritoqualine

Tritoqualine

CAS No.: 14504-73-5
M. Wt: 500.54100
M. Fa: C26H32N2O8
InChI Key: IRGJVQIJENCTQF-UHFFFAOYSA-N

Names and Identifiers of Tritoqualine

CAS Number

14504-73-5

EC Number

858-360-7

IUPAC Name

7-amino-4,5,6-triethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one

InChI

InChI=1S/C26H32N2O8/c1-6-31-23-17-16(18(27)24(32-7-2)25(23)33-8-3)26(29)36-21(17)19-15-13(9-10-28(19)4)11-14-20(22(15)30-5)35-12-34-14/h11,19,21H,6-10,12,27H2,1-5H3

InChIKey

IRGJVQIJENCTQF-UHFFFAOYSA-N

Canonical SMILES

CCOC1=C(C(=C(C2=C1C(OC2=O)C3C4=C(C5=C(C=C4CCN3C)OCO5)OC)N)OCC)OCC

UNII

F4MW5166YH

Physical and chemical properties of Tritoqualine

Acidity coefficient

6.22±0.40(Predicted)

Boiling Point

647.2ºC at 760mmHg

Density

1.296g/cm3

Exact Mass

500.21600

Flash Point

345.2ºC

Index of Refraction

1.595

LogP

4.16200

Melting Point

183°

Molecular Formula

C26H32N2O8

Molecular Weight

500.54100

PSA

110.94000

Storage condition

2-8℃

Vapour Pressure

1.22E-16mmHg at 25°C

Applications of Tritoqualine

Tritoqualine is primarily used in clinical settings for the treatment of allergic conditions such as:

  • Urticaria: Reducing hives and itching.
  • Allergic Rhinitis: Alleviating symptoms such as sneezing and nasal congestion.

Its unique action mechanism makes it suitable for patients who experience adverse effects from conventional antihistamines. Additionally, research into its potential applications in other therapeutic areas continues, given its inhibitory effects on histamine production.

Interaction Studies of Tritoqualine

Tritoqualine has been studied for its interactions with various drugs and biological systems. Notably, it may enhance the anticholinergic effects of other medications such as Hyoscyamine. Furthermore, interactions with imaging agents like Iofetamine I-123 have been observed, indicating that Tritoqualine may influence sedative activities. Understanding these interactions is crucial for optimizing therapeutic regimens and minimizing adverse effects in clinical practice.

Biological Activity of Tritoqualine

Tritoqualine exhibits notable biological activity as an antihistamine. Its inhibition of histidine decarboxylase leads to reduced histamine release, thus alleviating symptoms associated with allergic reactions. Studies have indicated that Tritoqualine does not have significant sedative effects, making it a favorable option for patients who require antihistamines without drowsiness. Furthermore, its unique mechanism allows it to be effective in managing conditions like urticaria and allergic rhinitis with minimal side effects.